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Written by: David W., PharmDMedically reviewed by: Microdose Vault, MDLast medically reviewed: October, 2026]Last updated: [October, 2026] Promethazine with codeine is a prescription cough medication that combines promethazine, a sedating antihistamine, with codeine, an opioid cough suppressant. It provides temporary relief of cough and upper respiratory symptoms associated with allergies or the common cold in […]